St. Paul University Quezon City (also known as SPUQC) is a private, sectarian and previously a women's college. Situated on a gentle slope of what was originally known as New Manila, the SPUQC campus now occupies an entire block bordered by busy Aurora Boulevard, Gilmore Avenue, Third street, and Dona Magdalena Hemady Street in Quezon City. In June 2006, SPUQC started to open its doors to young men who desire to undergo their college education and formation in St. Paul University of Quezon City. The High School department followed suit when the first set of graduates from the co-ed Grade School enrolled in the High School in June 2008.

St. Paul University of Quezon City is recognized by the Department of Education and the Commission on Higher Education and also a charter member of the Philippine Accrediting Association of Schools, Colleges and Universities. It has earned Level III accreditation on all of its respective departments and schools. On May 2012, PAASCU granted re-accredited status to the Science, Liberal Arts, and Business Programs (except accountancy).